From Searle's Freedom & Neurobiology:
"There is exactly one overriding question in contemporary philosophy. [...] How do we fit in? [...] How can we square this self-conception of ourselves as mindful, meaning-creating, free, rational, etc., agents with a universe that consists entirely of mindless, meaningless, unfree, nonrational, brute physical particles?(Hat tip to CoW.)
For the scientific naturalist, the answer is, 'Not very well.'"